CoQ10 and Fertility: What Does the Research Say

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Below you will find a summary of research on the role of CoQ10 in both male and female fertility. Please see the references at the bottom of the page for links to the research articles on CoQ10 and fertility.

What is CoQ10?

CoQ10 is a nutrient-like coenzyme that plays an important role in the production of 95% of the energy needed by your cells, including sperm and egg cells. It is also a powerful antioxidant that protects your cells from molecules that may cause damage. Your CoQ10 levels can drop due to age, stress, and cholesterol-lowering statin drug therapy, and taking a CoQ10 supplement can help replenish your CoQ10 back to optimal levels.1

The Role of CoQ10 in Male Fertility

Stress, sun exposure, and smoking can cause your body to make molecules called reactive oxygen species (ROS). While the term ROS may be unfamiliar to you, you have likely heard people talking about “free radical damage”. Free radicals are a type of ROS and while your body naturally makes ROS and free radicals, in excess, these molecules can cause damage to healthy cells. In fact, research shows that male sperm cells can be damaged by excess ROS which may have a negative effect on male fertility.2,3

Antioxidants can help protect your cells from ROS damage and taking antioxidants has been associated with increased sperm cell concentration and motility.4,5,6 These are both important factors in male fertility! CoQ10 is a powerful antioxidant that can help neutralize excess ROS.7 Therefore, CoQ10 may be necessary to support healthy sperm function.8

CoQ10 is a powerful antioxidant that may be necessary to support healthy sperm function.7,8

The Role of CoQ10 in Female Fertility

As women age, their ability to get pregnant decreases because total egg supply and egg quality drop with age.9 Egg cells must mature before they can be fertilized and this process requires energy in the form of a molecule called adenosine triphosphate (or ATP for short!).10,11 ATP is produced within our cells and provides the energy needed for most of the reactions in our bodies. In order to get pregnant, a fertilized egg must implant itself into the lining of the uterus and research has shown that the ATP content of eggs is associated with their potential to implant.12

CoQ10 plays a vital role in the production of ATP. Therefore, healthy CoQ10 levels may be needed to support the normal functions of egg cells.13 Since CoQ10 levels decline starting at age 21 and can drop with aging1, women may need to supplement with CoQ10 to help support fertility.

CoQ10 plays a vital role in the production of energy required by egg cells and may support their normal functions.10,11,12,13

Water-Soluble Qunol® CoQ10 is the Better Choice

Qunol® CoQ10’s patented formulation is water and fat-soluble, unlike regular14 CoQ10 that does not dissolve in water and dissolves poorly in fat. Studies show that Qunol® Ultra CoQ10 is up to 3X better absorbed than regular114 CoQ10 so it can help you reach optimal levels of CoQ10 in just weeks – rather than months, so you can experience the potential benefits faster.15

References

1Fuke C, Krikorian SA, Couris RR. Coenzyme Q10: a review of essential functions and clinical trials. US Pharmacist. 2000; 25(10), 28-41.

2Aitken RJ, Clarkson JS, Fishel S. Generation of reactive oxygen species, lipid peroxidation and human sperm function. Biol Reprod. 1989;40:183–97.

3Rao B, Soufir JC, Martin M, David G. Lipid peroxidation in human spermatozoa as related to midpiece abnormalities and motility. Gamete Res. 1989;24:127–34.

4Eskenazi B, Kidd SA, Marks AR, Sloter E, Block G, Wyrobek AJ. Antioxidant intake is associated with semen quality in healthy men. Hum Reprod. 2005;20(4):1006–12.

5Sheweita S, Tilmisany A, Al-Sawaf H. Mechanisms of male infertility: role of antioxidants. Curr Drug Metab. 2005;6(5):495–501.

6Ross C, Morriss A, Khairy M, Khalaf Y, Braude P, Coomarasamy A, et al. A systematic review of the effect of oral antioxidants on male infertility. Reprod Biomed Online. 2010;20(6):711–23.

7Magnus, B., Kerstin, B., Gustav, D. (2007). The antioxidant role of coenzyme Q. Mitochondrion, 7S, S41-S50.

8Lafuente R, González-Comadrán M, Solà I, López G, Brassesco M, Carreras R, et al. Coenzyme Q10 and male infertility: a meta-analysis. J Assis Reprod Gen. 2013;30:1147–1156.

9Faddy MJ. Follicle dynamics during ovarian ageing. Mol. Cell. Endocrinol. 2000;163:43–48.

10Dumollard R, Ward Z, Carroll J, Duchen MR. Regulation of redox metabolism in the mouse oocyte and embryo. Development. 2007;134:455–465.

11Dalton CM, Szabadkai G, Carroll J. Measurement of ATP in single oocytes: impact of maturation and cumulus cells on levels and consumption. J. Cell. Physiol. 2014;229:353–361.

12Van Blerkom J, Davis PW, Lee J. ATP content of human oocytes and developmental potential and outcome after in-vitro fertilization and embryo transfer. Hum. Reprod. 1995;10:415–424.

13BenMeir A, Burstein E, BorregoAlvarez A, Chong J, Wong E, Yavorska T, Naranian T, Chi M, Wang Y, Bentov Y, Alexis J, Meriano J, Sung HK, Gasser DL, Moley KH, Hekimi S, Casper RE, Jurisicova A. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell. 2015;14(5):887–895.

14Regular CoQ10 refers to unsolubilized ubiquinone in oil suspensions in soft gels and/or powder filled capsules/tablets

15Chopra, R.K., et al. (1998). Bioavailability of Coenzyme Q1O in Humans. Internal. J. Vit. Nutr, Res. 68, 109-113. Received for publication August 4, 1997.

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